Background: The Wnt gene family encodes secreted signaling molecules that bind to frizzled receptors and influence oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis. The Wnt family has two functional classes according to their biological activities; Wnts that signal through a Wnt-1/wingless pathway by stabilizing cytoplasmic beta-catenin, and Wnts that stimulate intracellular Ca2+ release and activate two kinases, CamKII and PKC, in a G protein-dependent manner. Wnt-7a guides the development of the anterior-posterior axis in the female reproductive tract, and influences uterine smooth muscle pattering and maintenance of adult uterine function. The human Wnt-7a gene maps to chromosome 3p25. The human Wnt-7b gene maps to chromosome 22q13.
Description: Rabbit polyclonal to WNT7A
Immunogen: KLH conjugated synthetic peptide derived from WNT7A
Specificity: ·Reacts with Human, Mouse, Pig, Chicken and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 39 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
