Background: ANKHD1 (ankyrin repeat and KH domain containing 1), also known as MASK or VBARP, is a 2,542 amino acid protein that localizes to the cytoplasm and contains one KH domain and 25 ankyrin repeats. Expressed ubiquitously as multiple alternatively spliced isoforms, one of which exhibits higher expression in spleen and another of which is present at high levels in brain and cervix, ANKHD1 functions as a scaffolding protein that interacts with SH-PTP2 and may be associated with tumor progression. Specifically, ANKHD1 is thought to posses anti-apoptotic effects that are essential for cell survival and may be associated with the abnormal phenotype of leukemia cells. The gene encoding ANKHD1 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome.
Description: Rabbit polyclonal to ANKHD1
Immunogen: KLH conjugated synthetic peptide derived from ANKHD1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 69 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
