Background: CD98 (4F2, CD98, MDU1, 4F2HC, 4T2HC, NACAE) is a disulfide-linked heterodimer composed of a glycosylated heavy chain and a non-glycosylated light chain. CD98 is a scaffolding protein that interacts with basolaterally expressed amino acid transporters and β1 integrins and can alter amino acid transport and cell adhesion, migration and branching morphogenesis. The heavy chain is a type II integral membrane protein. CD98 is expressed on T cells and is upregulated upon T cell activation. CD98 is also present on monocytes and at lower levels on granulocytes, platelets and lymphocytes. Evidence suggests that CD98 may play a role in the regulation of T cell activation and proliferation. Alternate transcriptional splice variants, encoding different isoforms exist for the human CD98 gene.
Description: Rabbit polyclonal to CD98
Immunogen: KLH conjugated synthetic peptide derived from CD98
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 68 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
