Background: Glucose serves as the major energy substrate of mammalian cells and is fundamental to metabolism. Glucose passage across cell membranes is mediated by a family of transporters termed glucose transporters, or Gluts, which are characterized by the presence of 12 membrane-spanning helices. The Glut family is divided into three subfamilies: class I (previously known as glucose transporters), which includes Glut1, Glut2, Glut3 and Glut4; class II (previously known as fructose transporters), which includes Glut5, Glut7, Glut9 and Glut11; and class III, which includes Glut6, Glut8, Glut10, Glut12 and the myoinositol transporter HMIT1. Glut10 is a 541 amino acid facilitative glucose transporter expressed in high amounts in liver and pancreas. It contains 12 transmembrane domains, with a hydrophilic intracellular loop between helices 6 and 7, and a potential N-linked glycosylation site, with a large extracellular loop between helices 9 and 10. The gene for Glut 10, SLC2A10, maps to chromosome 20q13.12, a region that is linked to type 2 diabetes.
Description: Rabbit polyclonal to GLUT10
Immunogen: KLH conjugated synthetic peptide derived from GLUT10
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 54 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
