Background: SLC7A6 (solute carrier family 7 member 6), also known as LAT3, LAT-2 or y+LAT-2 (Y+L amino acid transporter 2), is a 515 amino acid multi-pass membrane protein belonging to the amino acid-polyamine-organocation (APC)superfamily and the L-type amino acid transporter (LAT) family. Expressed in normal fibroblasts, HUVECs (human umbilical vein endothelial cells), monocytes, RPE (retinal pigment epithelial) cells and various carcinoma cell lines,SLC7A6 is involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. SLC7A6 also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC7A6 may exist as a disulfide-linked heterodimer with the amino acid transport protein CD98. SLC7A6 plays a role in nitric oxide synthesis in HUVECs via transport of L-arginine, and is involved in the transport of L-arginine in monocytes and reduces uptake of ornithine in RPE cells.
Description: Rabbit polyclonal to SLC7A6
Immunogen: KLH conjugated synthetic peptide derived from SLC7A6
Specificity: ·Reacts with Human, Mouse, Pig and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 57 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-100;
·Immunocytochemistry: 1/100;
·Optimal working dilutions must be determined by the end user.
