Background: Protocadherins (PCDHs) are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH11X (protocadherin 11 X-linked), a 1,347 amino acid protein, and PCDH11Y (protocadherin 11 Y-linked), a 1,340 amino acid protein, are single-pass type I membrane proteins that each contain seven cadherin domains and each exist as multiple alternatively spliced isoforms. Expressed strongly in both adult and fetal brain tissue, PCDH11X and PCDH11Y function as calcium-dependent cell adhesion proteins that are essential for the segmental development and function of the central nervous system. Variations in the PCDH11X and PCDH11Y genes are associated with an increased susceptibility to brain-related afflictions, such as late-onset Alzheimer's disease.
Description: Rabbit polyclonal to PCDH11X
Immunogen: KLH conjugated synthetic peptide derived from PCDH11X
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 147 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
