Background: Sphingosine-1-phosphate lyase (SP-lyase) is a member of the group ll decarboxylase family that is involved in lipid metabolism. SP-lyase has a variety of functions contributing to normal development, including maintenance of the reproductive system, stress responses, tissue integrity and cell survival. Located in the membrane of the endoplasmic reticulum, SP-lyase is responsible for the irreversible degradation of sphingosine-1-phosphate (S1P). S1P is a lipid important in cell proliferation and migration and, once cleaved by SP-lyase, is degraded into fatty acids and phosphoethanolamine. Through its ability to regulate S1P expression, SP-lyase may play a role in stress-induced apoptosis and is thought to exhibit tumor suppressor activity by silencing S1P activity. Current research suggests that SP-lyase may be a useful target for cancer therapy drugs, as increasing its expression during tumorigenesis may help to regulate cell proliferation.
Description: Rabbit polyclonal to SGPL1
Immunogen: KLH conjugated synthetic peptide derived from SGPL1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 64 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
