Background: The interleukins (ILs) are a broad family of well characterized cytokines, primarily of hematopoietic cell origin. They are secreted by immune cells (mainly macrophages, B cells or T cells) that regulate a wide range of immune system functions. The specific functions of different interleukins vary from the regulation of inflammatory and immune responses to the regulation of other interleukins. IL-29, also known as interferon-λ1 (IFN-λ1) is a class II cytokine that stimulates its response through a heterodimeric receptor composedof IL-10Rβ and IL-28RA. It is induced by viral infection and exhibits antiviral and antiproliferative activity. In addition, IL-29 may play a role in immunoregulation. It stimulates an identical response as IFN-α but utilizes a different receptor. In addition, IL-29 may be a useful therapeutic agent against chronic viral hepatitis.
Description: Rabbit polyclonal to IL29
Immunogen: KLH conjugated synthetic peptide derived from IL29
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 22 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
