Background: SYF2 (SYF2 homolog, RNA splicing factor), also known as CCNDBP1-interactor or p29, is a 243 amino acid protein belonging to the SYF2 family. Localizing to nucleus, SYF2 is highly expressed in heart, skeletal muscle and kidney. SYF2 is likely involved in pre-mRNA splicing and cell cycle progression, and may function as a DNA replication checkpoint regulator. The gene encoding SYF2 maps to human chromosome 1p36.11. As the largest human chromosome, chromosome 1 spans about 260 million base pairs and makes up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
Description: Rabbit polyclonal to GCIP interacting protein p29
Immunogen: KLH conjugated synthetic peptide derived from GCIP interacting protein p29
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 29 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
