Background: LMO3 (LIM domain only 3), also known as RBTN3 (Rhombotin-3), RBTNL2 or RHOM3, is a 145 amino acid protein that contains two LIM zinc-binding domains and may be involved in transcriptional regulation events in tissues throughout the body. Aberrant expression of LMO3 is associated with the genesis and progression of human neuroblastoma, suggesting a role for LMO3 in oncogenesis. The gene encoding LMO3 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
Description: Rabbit polyclonal to LMO3
Immunogen: KLH conjugated synthetic peptide derived from LMO3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 17 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
