Background: Kruppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation and embryogenesis. Individual members of the Sp1-like/KLF family can function either as activators or repressors, depending on which promoter they bind and which coregulators they interact with. KLF14 (Kruppel-like factor 14), also known as BTEB5 (basic transcription element-binding protein 5), is a 323 amino acid protein that localizes to the nucleus and contains three C2H2-type zinc fingers, suggesting a role in transcriptional regulation. The gene encoding KLF14 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, lissencephaly, citrullinemia and Shwachman-Diamond syndrome.
Description: Rabbit polyclonal to KLF14
Immunogen: KLH conjugated synthetic peptide derived from KLF14
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 33 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
