Background: ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of Cholera Toxin. ARF’s are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL11 (ADP-ribosylation factor-like 11), also known as ARLTS1 (ADP-ribosylation factor-like tumor suppressor protein 1), is a 196 amino acid protein that belongs to a family of ARF-like proteins. Expressed in leukocytes and lung tissue, ARL11 is thought to function as a tumor suppressor that may play a role in the regulation of apoptosis. Defects in the gene encoding ARL11 are associated with an increased susceptibility to chronic lymphocytic leukemia (CLL), melanoma and colorectal cancer.
Description: Rabbit polyclonal to ARL11
Immunogen: KLH conjugated synthetic peptide derived from ARL11
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 21 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
