Catalog Number: PR-1559
Background: Endomucin is a mucin like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. Two types of endomucin are identified that are termed Endomucin 1 and Endomucin 2. Exogenously expressed human Endomucin 1 and 2 are modified into 80-120 kDa glycoproteins. Both Endomucin 1 and Endomucin 2 negatively regulate cell adhesion to the extracellular matrix. Overexpression of Endomucin 1 inhibits adhesion and aggregation of hematopoietic cells, suggesting that Endomucin 1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis.
Description: Rabbit polyclonal to Endomucin
Immunogen: KLH conjugated synthetic peptide derived from Endomucin
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 27 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/1000;
·Optimal working dilutions must be determined by the end user.
