Background: Psoriasin/HID-5/S100A7 was originally identified as an up-regulated protein in psoriatic keratinocytes. Subsequently, this protein was found to have elevated expression in abnormally differentiating primary keratinocytes and in various carcinomas, including ductal carcinoma in situ. Psoriasin/HID-5/S100A7 may play a role in the establishment or maintenance of these pathologies, and may serve as a diagnostic marker of particular tumour types or abnormally proliferative epithelia. Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.
Description: Rabbit polyclonal to Psoriasin
Immunogen: KLH conjugated synthetic peptide derived from Psoriasin
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 12 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
