Background: CD3/T cell receptor (TcR) complex is made up of at least five CD3 proteins (gamma, delta, epsilon, h, z) in association with either alpha/beta or gamma/delta proteins of the TcR (2). The TcR recognizes antigens in association with MHC molecules after which protein chains of the CD3 complex mediate activation signals triggered by TcR antigen binding. CD3 is expressed on greater than 95% of circulating human peripheral T cells. The CD3 complex mediates signal transduction. Subcellular location: Membrane; Single-pass type I membrane protein.
Description: Mouse monoclonal to CD3
Immunogen: KLH conjugated synthetic peptide derived from CD3
Specificity: ·Recognizes Human CD3 epsilon chain in Immunohistochemiscal staining.
·Isotype: IgG
Application: ·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Optimal working dilutions must be determined by the end user.
