Background: The NACHT-, LRR- and PYD-containing protein (NALP) family functions in the regulation of apoptosis and inflammatory signaling pathways. Members of the NALP family (also designated Pyrin-containing APAF1-like proteins) include NALP1 through NALP11. Several family members, such as NALP1, NALP2, NALP3 and NALP6, influence NF˚B and caspase pathways as components of the inflammasome. NALP10 is a member of the NALP family that lacks the LRR region but also may play a regulatory role in the innate immune system. NALP10 inhibits NF˚B activation as well as apoptosis induced by ASC. It is highly expressed in brain, heart and skeletal muscle and is regulated by Annexin A7 in a mechanism that may be involved with tumorgenesis.
Description: Rabbit polyclonal to NLRP10
Immunogen: KLH conjugated synthetic peptide derived from NLRP10
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 75 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
