Background: KLHL31, also known as kelch-like protein 31, BTB and kelch domain-containing protein 6, kelch-like protein KLHL or kelch repeat and BTB domain-containing protein 1, is a 634 amino acid protein similar to the Drosophila kelch protein. KLHL31 is expressed strongly in skeletal muscle and weakly in heart. KLHL31 contains one BACK (BTB/kelch associated) domain, which may indicate a role in substrate orientation in E3 ligase complexes. KLHL31 also contains six kelch repeats and one BTB (POZ) domain. The BTB (broad complex, tramtrack and bric-a-brac) domain, also known as the POZ (Poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function.
Description: Rabbit polyclonal to KLHL31
Immunogen: KLH conjugated synthetic peptide derived from KLHL31
Specificity: ·Reacts with Human, Mouse, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/200-500. Predicted Mol wt: 70 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
