Background: The URB protein, also designated coiled-coil domain-containing protein 80 (CCDC80) or Down-regulated by oncogenes protein 1 (DRO1), is secreted from adipocytes and is thought to play a role in obesity. Loss of URB function inhibits adipocyte differentiation, down-regulates WNt/β-catenin signaling and induces activation of C/EBPα and peroxisome proliferator-activated receptor gamma (PPARγ). URB is also expressed in dermal papilla and dermal fibroblasts as well as heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts. Reduced expression of URB is observed in colon, colorectal and pancreatic cancer cell lines, suggesting an important role for URB in the pathogenesis of neoplasms. Three isoforms of URB exist as a result of alternative splicing events.
Description: Rabbit polyclonal to CCDC80
Immunogen: KLH conjugated synthetic peptide derived from CCDC80
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/200-500. Predicted Mol wt: 108 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
