Background: ALP (actinin-associated LIM protein), also known as PDLIM3 (PDZ and LIM domain protein 3) is a 364 amino acid protein that contains one LIM zinc-binding domain and one PDZ domain and localizes to the cytoplasm, as well as to myofiber Z-lines. Existing as three alternatively spliced isoforms, two of which exhibit tissue-specific expression in skeletal muscle and heart, ALP interacts with å-actinin-2 and, via this interaction, is thought to play a role in Actin filament organization, specifically regulating the association of Actin filaments arrays with muscle cells. The gene encoding ALP maps to a region on human chromosome 4 that is associated with facioscapulohumeral muscular dystrophy, suggesting that defects in the ALP gene may be involved in the pathogenesis of muscular dystrophy.
Description: Rabbit polyclonal to PDLIM3
Immunogen: KLH conjugated synthetic peptide derived from PDLIM3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 39 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
