Background: ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain, and a carboxy-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. The human ADAMTS9 gene maps to chromosome 3p14.1 and encodes a deduced 1,1471 amino acid protein that is expressed in ovary, pancreas, heart, lung, placenta, adult kidney, and fetal tissues. Human chromosome 3p14.1 is a region that is known to contain deletions and rearrangements in renal cell carcinomas, breast cancers, uterine cervical carcinomas, and vulvar carcinomas.
Description: Rabbit polyclonal to ADAMTS9
Immunogen: KLH conjugated synthetic peptide derived from ADAMTS9
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 217/183/121 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
