Background: G protein-coupled receptors (GPCRs) are the largest superfamily of related proteins. All have 7-transmembrane segments and allow cells to sample and respond to their environment. MASS1 (for monogenic audiogenic seizure susceptibility 1) is one of the largest known GPCRs and is therefore referred to as Very Large G protein-coupled receptor 1 (VLGR1). MASS1 is a large, calcium-binding GPCR expressed in the central nervous system and the eye. MASS1 has a large ectodomain containing multiple calcium exchanger beta repeats that resemble regulatory domains of sodium-calcium exchanger proteins. The human MASS1 gene maps to chromosome 5q14 and encodes a 1967 amino acid protein. The MASS1 gene has been linked to the autosomal recessive inheritance of general epilepsy in Frings mice that have seizures in response to loud noises.
Description: Rabbit polyclonal to MASS1
Immunogen: KLH conjugated synthetic peptide derived from MASS1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 220 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
