Background: RCC2 (regulator of chromosome condensation 2), also known as KIAA1470 or TD60, is a 522 amino acid protein that contains seven RCC1 repeats and is expressed in a variety of mammalian tissues. Localized to the nucleus, as well as to centromeres and the midzone of the mitotic spindle in a cell-cycle dependent manner, RCC2 binds to Rac 1 and is required for the completion of mitosis and cytokinesis, possibly functioning as a guanine nucleotide exchange factor for Rac 1. RCC2 is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding RCC2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Description: Rabbit polyclonal to RCC2
Immunogen: KLH conjugated synthetic peptide derived from RCC2
Specificity: ·Reacts with Human, Mouse, Rabbit, Dog, Pig and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 56 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
