Background: NCX1, also known as Sodium Calcium Exchanger 1 is an integral membrane protein expressed in the plasma membrane of virtually all cells, and transports calcium in bi-directional modes. NCX1 rapidly transports calcium during excitation-contraction coupling. Several alternatively spliced isoforms exist. Dysfunction of NCX1 may be associated with heart failure and ischemia. The expression and protein levels of the Na(+)/Ca(2+) exchanger (NCX-1) vary during heart development and in response to changes in thyroid hormone levels. The expression of the NCX-1 gene is two-fold higher in the fetal heart of mouse versus adult. In addition, NCX-1 mRNA and protein levels were upregulated in hypothyroidic hearts. In hyperthyoidic hearts this response was reversed, however.
Description: Rabbit polyclonal to NCX1
Immunogen: KLH conjugated synthetic peptide derived from NCX1
Specificity: ·Reacts with Human, Mouse, Chicken and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 108 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
