Background: RASAL1 (Ras protein activator like 1) is an 804 amino acid protein that exists as two alternatively spliced isoforms and contains one Rag-GAP domain, one PH domain, one Btk-type zinc finger and two C2 domains. Expressed at high levels in thyroid and adrenal medulla and present at lower levels in trachea, brain and spinal cord, RASAL1 is thought to function as an inhibitory regulator of the Ras-cyclic AMP pathway, possibly enhancing Ras GTPase activity and playing a role in the regulation of cellular proliferation and differentiation. Lowered expression of RASAL1 is associated with the progression of several types of human cancers, suggesting a role for RASAL1 in tumor suppression and apoptotic control.
Description: Rabbit polyclonal to RASAL1
Immunogen: KLH conjugated synthetic peptide derived from RASAL1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 90 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
