Background: PDL2 has been reported to be stimulatory on dendritic cells when cross linked and to inhibit T cell activation upon engaging the PD1 receptor. PDL2 has also been reported to bind to an alternative receptor and to mediate T cell activation through non PD1 mediated interactions. Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Description: Rabbit polyclonal to PDL2
Immunogen: KLH conjugated synthetic peptide derived from PDL2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 30 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
