Background: In Xenopus, Gremlin 1 belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Gremlin 1(CKTFS1B1) is localized on human chromosome 15q13--> q15. Gremlin 1-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of Gremlin 1 is associated with tumor progression, and support the hypothesis that human Gremlin 1 may play an important role during both neuroembryological development and carcinogenesis.
Description: Rabbit polyclonal to Gremlin
Immunogen: KLH conjugated synthetic peptide derived from Gremlin
Specificity: ·Reacts with Human, Mouse, Rabbit, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 20 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/200-500;
·Immunocytochemistry: 1/100-500;
· ELISA:1/1000;
·Optimal working dilutions must be determined by the end user.
