Background: PEG10 (Paternally expressed gene 10) inhibits TGF beta signaling by interacting with the TGF beta receptor ALK1. It is able to prevent apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. PEG10 is a mammalian gene that has been shown to be essential for embryonic development and is highly conserved in therian mammals. PEG10 has evolved from a retroelement into a gene that is required during prenatal development and has maintained its ability to carry out –1 frameshifting to express two proteins from the same mRNA (ORF1 and ORF2). This is the first demonstration of –1 frameshifting for gene expression in animal tissues and is the highest frameshift efficiency reported.
Description: Rabbit polyclonal to PEG10
Immunogen: KLH conjugated synthetic peptide derived from PEG10
Specificity: ·Reacts with Human, Mouse, Pig, Dog, Cow and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 36/80 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
