Background: IQGAP1 is a widely expressed protein than interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology. It binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Description: Rabbit polyclonal to IQGAP1
Immunogen: KLH conjugated synthetic peptide derived from IQGAP1
Specificity: ·Reacts with Human, Mouse and Rat
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 189 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
