Background: UZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. SUZ12 is a component of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3.
Description: Rabbit polyclonal to SUZ12
Immunogen: KLH conjugated synthetic peptide derived from SUZ12
Specificity: ·Reacts with Human, Mouse, Rabbit, Pig, Dog, Cow and Rat
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 75 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;
·Immunocytochemistry: 1/100;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
