Background: The ACTH receptor(ACTHR) is a type of melanocortin receptor (type 2), properly known as MC2, which is specific for ACTH. It is found in the zona fasciculata of the human adrenal cortex. Binding of the receptor by ACTH stimulates the production of cortisol. (By contrast, aldosterone production from the zona glomerulosa is stimulated primarily by angiotensin II.) The ACTH receptor uses cAMP as a secondary messenger. ACTHR encodes one member of the five-member G-protein associated melanocortin receptor family. ACTHR is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in this receptor cause familial glucocorticoid deficiency type 1, in which patients have high levels of serum ACTH and low levels of cortisol.
Description: Rabbit polyclonal to ACTHR
Immunogen: KLH conjugated synthetic peptide derived from ACTHR
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 34 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
