Background: CFTR (cystic fibrosis transmembrane conductance regulator) the membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This gene encodes the cystic fibrosis transmembrane regulator and a chloride channel that controls the regulation of other transport pathways. Mutations in this gene have been associated with autosomal recessive disorders such as cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternative splicing of exons 4, 5, and11 have been observed, but full-length transcripts have not yet been fully described. Belongs to the ABC transporter family.
Description: Rabbit polyclonal to CFTR
Immunogen: KLH conjugated synthetic peptide derived from CFTR
Specificity: ·Reacts with Human, Mouse, Rat, Rabbit, Cow, Dog and Pig.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 168 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
