Background: The aquaporins are small, very hydrophobic, intrinsic membrane proteins, the selectivity of which can be so high that even protons (H3O+) cannot pass, although some channels also transport glycerol and sometimes larger molecules in addition to water. All aquaporins bear common structural features, containing intracellular N- and C- termini and six transmembrane segments separated by five connecting loops. Aquaporin-mediated water flow in vivo is directed by osmotic or hydraulic gradients and most mammalian aquaporins are inhibited by mercurials. Aquaporin 5 (AQP5) is expressed in secretory glands, lung and eye, where it works in modulating the rate of fluid release. Since a number of pathological conditions including Sjögren’s syndrome, pulmonary oedema, respiratory distress syndrome and congestive heart failure are characterized by disrupted fluid transport, it has been suggested that modulation of the expression of AQP5 could be a novel modality of treatment of some of the above illnesses.
Description: Rabbit polyclonal to AQP5
Immunogen: KLH conjugated synthetic peptide derived from AQP5
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 29 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
