Background: Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.
Description: Rabbit polyclonal to IL-17RA
Immunogen: KLH conjugated synthetic peptide derived from IL-17RA
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 96 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-020;
·Immunocytochemistry: 1/100;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
