Background: Retinol-binding protein 4 (RBP4) is a small transport protein (~ 23 kDa) and belongs to the lipocalin family with diverse functions. It is the specific carrier protein for retinol (vitamin A alcohol) in the serum. It delivers retinol from the liver stores to the peripheral tissues. In human plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. Recently, RBP4 was known to be one of adipokine secreted by adipocytes and relate to insulin resistance in the AG4KO mouse model. RBP4 may contribute to pathogenesis of type 2 diabetes. Yang et al. demonstrated that serum RBP4 levels are elevated in patients with obesity and type 2 diabetes.
Description: Rabbit polyclonal to RBP4
Immunogen: KLH conjugated synthetic peptide derived from RBP4
Specificity: ·Reacts with Human, Mouse, Rabbit, Dog, Pig, Cow and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/500-1000. Predicted Mol wt: 23 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/200-500;
·ELISA: 1/1000;
· Optimal working dilutions must be determined by the end user.
