Background: Melatonin is a natually occurring secreted hormone that exhibits antioxidant capabilities and is crucial in the proper regulation of the circadian rhythm. HIOMT (hydroxyindole O-methyltransferase), is a 345 amino acid protein that belongs to the methyltransferase superfamily and is involved in melatonin biosynthesis. Expressed in brain, retina and pineal gland, ASMT functions to catalyze the final reaction in the synthesis of melatonin, specifically the conversion of S-adenosyl-L-methionine and N-acetylserotonin to S-adenosyl-L-homocysteine and melatonin.
Description: Rabbit polyclonal to HIOMT
Immunogen: KLH conjugated synthetic peptide derived from HIOMT
Specificity: ·Reacts with Human, Mouse, Dog, Cow, Sheep and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 38 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-100;
·Immunocytochemistry: 1/100;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
