Background: Members of the C2H2 zinc finger family bind GC-rich motifs widely distributed in gene promoters, resulting in distinct activation or repression of transcriptional activities. In addition to Sp1, Sp2, Sp3, and Sp4, the basic transcription element binding proteins-1 and -2 (BTEB1 and BTEB2, respectively), belong to this family of transcriptional regulators. BTEB2 binds the GC-box of DNA and is expressed in fetal aorta. BTEB2 is a target for Egr-1. Expression of BTEB2 is activated by mitogen-activated protein kinase pathways. BTEB2 expression is induced in the neointima in response to vascular injury and is involved in phenotypic modulation of vascular smooth muscle cells in response to mitogen stimulation through Egr-1.
Description: Rabbit polyclonal to KLF5
Immunogen: KLH conjugated synthetic peptide derived from KLF5
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 51 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
