Background: Breast cancer resistance protein (BCRP ) is an ABC superfamily member; when expression of BCRP is enforced by transfection of the cDNA in drug-sensitive human breast cancer MCF-7 cells, the cloned transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of Rhodamine 123 compared to vector transfected controls.
Description: Rabbit polyclonal to BCRP
Immunogen: KLH conjugated synthetic peptide derived from BCRP
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 72 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
