Background: C-erbB-2 (also designated receptor protein-tyrosine kinase erbB-2; p185erbB2; Neu proto-oncogene ;Tyrosine kinase-type cell surface receptor,HER2; Epidermal growth factor receptor-related protein)Essential component of a neuregulin-receptor complex althought neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF,TGF-alpha and amphiregulin. [SUBUNIT] Heterodimer with each of ,the other ERBB receptors. The constitutively activated oncogenic variant forms a homodimer. Interacts with PRKCABP and PLXNB1. It is a type I membrane protein. Ligand-binding increases phosphorylation on tyrosine residues Belongs to the Tyr protein kinase family. EGF receptor subfamily.
Description: Rabbit polyclonal to C-erbB-2
Immunogen: KLH conjugated synthetic peptide derived from C-erbB-2
Specificity: ·Reacts with Human.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 138 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·ELISA:1/500;
·Optimal working dilutions must be determined by the end user.
