Background: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. Alternate Names: AP endonuclease 1; AP endonuclease class I; AP lyase; APE 1 ; APE; APEN ; APEX 1 ; APEX; APEX nuclease (multifunctional DNA repair enzyme) 1; Apex nuclease 1; Apex nuclease; APEX1; Apurinic/apyrimidinic (abasic) endonuclease; Apurinic/apyrimidinic exonuclease; APX ; Deoxyribonuclease (apurinic or apyrimidinic) ; DNA (apurinic or apyrimidinic site) lyase; HAP 1; HAP1; Multifunctional DNA repair enzyme; Redox factor 1; REF 1; REF 1 protein ; REF1; REF1 protein.Description: Rabbit polyclonal to APEX1
Immunogen: KLH conjugated synthetic peptide derived from APEX1
Specificity: ·Reacts with Human, Mouse, Pig, Cow, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 37 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/1000;
·Optimal working dilutions must be determined by the end user.
