Background: Bcl-8 (B-cell CLL/lymphoma 8) is a 100 amino acid protein that is expressed in prostate and testis. The Bcl-8 family provides examples of both types of segmental duplication: interchromosomal and intrachromosomal. A chromosomal aberration involving Bcl-8 exists in diffuse large cell lymphoma (DLCL). The Bcl-8/IgH translocation leaves the coding region of Bcl-8 intact, but may have pathogenic effects due to alterations in the expression level of Bcl-8. The Bcl-8 gene is not normally expressed in lymphoid tissues, but its expression can be activated by chromosomal translocation or by other mechanisms in DLCL.
Description: Rabbit polyclonal to BCL8
Immunogen: KLH conjugated synthetic peptide derived from BCL8
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 330 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
