Background: Interferon regulatory factor-4 (IRF-4) belongs to the IRF family of DNA-binding factors which regulate both interferon and interferon-inducible genes. Family members include IRF-1–7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP). IRF-4 is also known as lymphocyte specific interferon regulatory factor (LSIRF), multiple myeloma oncogene 1 and PU.1 interaction partner (Pip). A nuclear protein specific to lymphoid cells, IRF-4 is a transcriptional activator that binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
Description: Rabbit polyclonal to IRF4
Immunogen: KLH conjugated synthetic peptide derived from IRF4
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 52 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
