Background: The human Laminin Alpha 2 Chain, also called Merosin Laminin Alpha 2 Chain, is necessary for sustenance of mature muscle cells. The Laminin Alpha 2 Chain is associated with congenital muscular dystrophy (CMD) in humans and dystrophia muscularis in mice. Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A) [MIM:607855]. MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
Description: Rabbit polyclonal to Laminin Alpha 2 Chain
Immunogen: KLH conjugated synthetic peptide derived from Laminin Alpha 2 Chain
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 300 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/100-200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
