Background: Histatin 1 is a histidine-rich phosphoprotein present in human parotid saliva that possesses candidacidal activity and functions in mineralization by adsorbing to hydroxyapatite. Phosphorylation of histatin 1 contributes to its ability to bind hydroxyapatite. Salivary histatins are a family of small histidine-rich peptides with potent antifungal activity. Submandibular and sublingual histatin secretion levels may affect the status of yeast present in the mouth. As a result, histatins have been implicated as potential therapeutic agents against oral candidiasis. A decrease in salivary histatins in relation to total salivary protein is common in old age and can influence the ability of the oral host defense system to address pathogens.
Description: Rabbit polyclonal to Histatin 1
Immunogen: KLH conjugated synthetic peptide derived from Histatin 1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 7 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
