Background: PACSINs are members of a family of cytoplasmic adapter proteins, which share a conserved, C-terminal, protein-binding SH3 domain and a CDC15-NT domain. PACSIN1-related proteins include syndapin 1 (the rat homolog of PACSIN1), FAP52, EM13 and PSTPIP, all of which seem to be involved in signaling pathways associated with cytoskeletal organization. PACSIN1 expression is restricted to terminally differentiated neural tissue, whereas PACSIN2 is widely expressed. PACSIN2 shows vesicle-like distribution and may be involved in regulating endocytotic processes.
Description: Rabbit polyclonal to PACSIN2
Immunogen: KLH conjugated synthetic peptide derived from PACSIN2
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 56 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
