Background: The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. Delta is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis, and in adult heart and lung.
Description: Rabbit polyclonal to DLL1
Immunogen: KLH conjugated synthetic peptide derived from DLL1
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 78 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
