Background: The chromosomal band of 3p21 is frequently deleted in several types of tumors, suggesting that this region may harbor multiple tumor suppressor genes. The DRR1 (down-regulated in renal cell carcinoma 1) gene, also known as FAM107A and Protein TU3A, is located in this critical chromosomal region and encodes a 144 amino acid nuclear protein that contains a coiled region, suggesting that the protein may function to regulate gene transcription and signal transduction. With the exception of peripheral blood cells, DRR1 is expressed in all normal tissues, but shows significant loss of expression in renal cell carcinomas and frequent loss of expression in cervical, gastric, ovarian and nonsmall cell lung cancers. Transfection of DRR1 mRNA into cancer cell lines inhibits cell growth and proliferation, supporting the evidence that the gene functions as an important tumor suppressor. There are two isoforms of DRR1 that exist as a result of alternative splicing events.
Description: Rabbit polyclonal to FAM107A
Immunogen: KLH conjugated synthetic peptide derived from FAM107A
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 17 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
