Background: Esophageal squamous cell carcinoma (ESCC) is cancer of the flat cells lining the esophagus, and is currently the ninth most frequent cancer in the world. While environmental risk factors, such as alcohol drinking and cigarette smoking, increase chances of ESCC, several genes are believed to be involved in the origin and/or progression of ESCC. The proteins encoded by these genes include p53, DCC, DEC1, DLEC1, p16 and TGFβRII. JK-1, also known as FAM134B, is a 497 amino acid multi-pass membrane protein. JK-1 overexpression in ESCC cell lines causes increased cell growth rate, indicating a possible role in ESCC progression. JK-1 is expressed as two isoforms produced by alternative splicing.
Description: Rabbit polyclonal to FAM134B
Immunogen: KLH conjugated synthetic peptide derived from FAM134B
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 54 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
