Background: HVCN1 (hydrogen voltage-gated channel 1), also known as HV1 or voltage sensor domain-only protein, is a 273 amino acid protein belonging to the hydrogen channel family. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. This proton conductance allows for the oxidative burst that is used for microbial killing by phagocytic leukocytes. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 is enriched in immune tissues and is expressed as three isoforms produced by alternative splicing.
Description: Rabbit polyclonal to HVCN1
Immunogen: KLH conjugated synthetic peptide derived from HVCN1
Specificity: ·Reacts with Human.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 32 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
