Background: Sel-1L3 (sel-1 suppressor of lin-12-like 3) is a 1,132 amino acid single-pass membrane protein that contains eight Sel1-like repeats. Existing as three alternatively spliced isoforms, the Sel-1L3 gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 4p15.2. Several independent linkage studies have identified chromosome 4p15–p16 as a putative region of susceptibility for bipolar disorder, schizophrenia and related phenotypes. Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Description: Rabbit polyclonal to SEL1L3
Immunogen: KLH conjugated synthetic peptide derived from SEL1L3
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 129 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
