Background: NUDT21 (nudix (nucleoside diphosphate linked moiety X)-type motif 21), also known as CPSF5 (cleavage and polyadenylation specificity factor subunit 5) or CFIm25 (cleavage and polyadenylation specificity factor 25 kDa subunit), is a member of the Nudix hydrolase family of pyrophosphatases. Nudix hydrolases contain a characteristic NUDIX domain and are responsible for catalyzing the hydrolysis of nucleoside diphosphate derivatives. NUDT21 localizes to the paraspeckles and forms a heterodimer with CPSF6 or CPSF7 to comprise the CFIm (mammalian Cleavage Factor I) complex. NUDT21 is the smaller subunit of the complex and is present in all heterodimer combinations. CFIm plays an important role in pre-mRNA 3’ cleavage and polyadenylation processing.
Description: Rabbit polyclonal to NUDT21
Immunogen: KLH conjugated synthetic peptide derived from NUDT21
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 26 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
